The recommended dose of Olumiant in patients taking strong Organic Anion Transporter 3 (OAT3) inhibitors is _____________.
a. 1 mg once daily
b. 2 mg once daily
c. 3 mg once daily
d. 4 mg once daily
e. Cannot be used with OAT3 inhibitors
Answer: (a). The active ingredient found in Olumiant is Baricitinib. It is a Janus kinase (JAK) inhibitor indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more TNF antagonist therapies.
1. The recommended dose of Olumiant (Baricitinib) in patients taking strong Organic Anion Transporter 3 (OAT3) inhibitors (e.g., probenecid) is 1 mg once daily.
2. The recommended dose of Olumiant (Baricitinib) in patients with moderate renal impairment is 1 mg once daily.
3. Olumiant (Baricitinib) is not recommended in patients with severe renal impairment.
4. Olumiant (Baricitinib) is not recommended in patients with severe hepatic impairment.
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